2. Signaling Pathways
  3. MAPK/ERK Pathway
  4. p38 MAPK
  5. p38 MAPK Agonist

p38 MAPK Agonist

p38 MAPK Isoform Comparison

p38 MAPK Agonists (3):

Cat. No. Product Name Effect Purity
  • HY-123942
    Diprovocim
    		Agonist 98.82%
    Diprovocim is a potent TLR1/TLR2 agonist. Diprovocim elicits full agonist activity in human THP-1 cells (EC50=110 pM). Diprovocim stimulates the release of TNF-α from mouse macrophages (EC50=1.3 nM). Diprovocim activates downstream MAPK and NF-κB signaling pathway. Diprovocim displays strong adjuvant activity in mice, particularly abetting cellular immune responses.
  • HY-173188
    EGFR-IN-154
    		Agonist
    EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC50 values of 0.16 μM, 21.73 μM and 41.56 μM against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels.
  • HY-N8835
    Cannabisin D
    		Agonist
    Cannabisin D inhibits proliferation and migration of glioblastoma cells through MAPKs signaling.